Apoptosis, Senescence, and Cancer - download pdf or read online

By Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)

ISBN-10: 1588295273

ISBN-13: 9781588295279

ISBN-10: 1597452211

ISBN-13: 9781597452212

Apoptosis, Senescence and melanoma offers perception into validated practices and study into apoptosis and senescence via completely studying novel and rising concepts and study within the fields of mobile dying pathways, senescence development arrest, medicinal drugs and resistance, DNA harm reaction, and different themes which nonetheless carry mysteries for researchers.

The quantity is split into six effortless to persist with sections. the 1st is Apoptosis and replacement Modes of mobile loss of life, via chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The 3rd half covers DNA harm reaction, Signaling Pathways and Tumorigenesis, whereas the fourth delves into Resistance and Sensitization. The ebook concludes with confirmed melanoma remedies and a piece which appears to be like towards the longer term with fresh and constructing melanoma Therapies.

In overall, this quantity offers simple scientists and clinicians with a deeper and extra whole realizing of the mobile responses of malignancies which can be certain the effectiveness of therapy, either within the preliminary levels of the affliction in addition to in disorder recurrence.

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Additional info for Apoptosis, Senescence, and Cancer

Example text

El-Deiry, MD, PhD Summary Defects in the extrinsic pathway are linked to several disease states, including cancer. Pharmacologic manipulation of the extrinsic pathway holds exciting promise for cancer treatment. This review will discuss the current understanding of the molecular signaling events that originate from extracellular sources to initiate apoptosis, how the pathway is activated by conventional chemotherapeutic agents, and novel opportunities to exploit the extrinsic pathway for cancer treatments.

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002; 111(3):331–42. 90. Antonsson B, Conti F, Ciavatta A, et al. Inhibition of bax channel-forming activity by Bcl-2. Science 1997; 277:370–72. 91. Epand RF, Martinou JC, Montessuit S, Epand RM, Yip CM. Direct evidence for membrane pore formation by the apoptotic protein Bax. Biochem Biophys Res Commun 2002; 298(5):744–9. 92. Kandasamy K, Srinivasula SM, Alnemri ES, et al. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.

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Apoptosis, Senescence, and Cancer by Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)


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